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产品 产品类型 重组蛋白

Human CD24 Protein


背景

肿瘤细胞能够在细胞膜上表达“别吃我(don't eat me)”信号蛋白,如CD47,PD-L1和B2M等,来逃避肿瘤微环境中巨噬细胞对肿瘤的吞噬清除作用。阻断这些“别吃我”信号分子以及其巨噬细胞上相应受体分子的单克隆抗体在一些肿瘤中显示了一定的治疗效应。研究表明CD24-Siglec-10相互作用抑制了巨噬细胞介导的抗肿瘤免疫反应中的作用。CD24-Siglec-10作为固有免疫检查点,可调控巨噬细胞介导的抗肿瘤免疫反应,CD24阻断或可成为肿瘤免疫治疗尤其是对乳腺癌或卵巢癌免疫治疗的新靶点。

应用

抗体发现:免疫,筛选,功能表征

亲和力测定:ELISA,SPR, BLI

血样测定:ELISA

产品列表

货号名称种属标签
CD2-HM324Human CD24 ProteinHumanmFc
CD2-HM624Human CD24 ProteinHumanLlama IgG2b Fc
CD2-HM224Human CD24 ProteinHumanhFc
SIG-HM210Human Siglec-10 ProteinHumanHis
SIG-HM510Human Siglec-10 ProteinHumanhFc
产品特点

高纯度,高亲和力数据。

  • CD24 mFc HPLC.png
    HPLC Data

    The purity of CD24 mFc is greater than 95% as determined by SEC-HPLC.

  • siglec10 HPLC.png
    HPLC Data

    The purity of Siglec-10  is greater than 95% as determined by SEC-HPLC.

  • CD24 mFc ELISA.png
    ELISA Data

    Immobilized Human CD24, mFc Tag at 0.2ug/ml (100ul/Well).Dose response curve for Anti-CD24 Ab.with the EC50 of 0.19ug/ml determined by ELISA.

  • CD24 Llama Fc ELISA - 副本.png
    ELISA Data

    Immobilized Human CD24, Llama IgG2b Fc Tag at 0.2ug/ml(100ul/Well).Dose response curve for Anti-CD24 Ab.with the EC50 of 0.12ug/ml determined by ELISA.

  • siglec10 ELISA.png
    ELISA Data

    Immobilized human Siglec-10 at 0.5ug/ml(100ul/well). Dose response curve for Anti-Siglec10 with the EC50 of 8.6ng/ml determined by ELISA. 

  • CD24 Fc ELISA.png
    ELISA Data

    Immobilized Human CD24, Fc Tag at 0.5ug/ml (100ul/Well).Dose response curve for biotinylated Anti-CD24 Ab.with the EC50 of 1ug/ml determined by ELISA.

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