400-614-0008

Human Siglec-10 Protein


Cat:SIG-HM210

Description

siglec10.png
Synonyms:

siglec 10; siglec-10; siglec10; Sialic acid-binding Ig-like lectin 10; Siglec-like protein 2; SLG2

Formulation and Storage

Formulation:

Supplied as 0.22um filtered solution in 20mM PB, 150mM Nal, 25mM Arginine(pH 7.4).

Storage:

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data

Tris-Bis PAGE
siglec10 gel.png

Recombinant Siglec-10 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

HPLC Data
siglec10 HPLC.png

The purity of Siglec-10  is greater than 95% as determined by SEC-HPLC.

ELISA data
siglec10 ELISA.png

Immobilized human Siglec-10 at 0.5ug/ml(100ul/well). Dose response curve for Anti-Siglec10 with the EC50 of 8.6ng/ml determined by ELISA.

Background

Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.

请在下面的消息框输入货号和规格信息,我们会尽快联系您!

* * * *

请在下面的消息框输入货号和批次号,我们会尽快联系您!

* * * *