400-614-0008

Cynomolgus CD3E&CD3G Protein


Cat:CD3-CM202

Description

CD3E&CD3G Gel.png
Synonyms:

CD3;CD3D;CD3-DELTA;T3D;CD3G

Formulation and Storage

Formulation:

Supplied as 0.22um filtered solution in PBS (pH 7.4).

Storage:

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data

Tris-Bis PAGE
CD3E CD3G gel.png

Recombinant Cynomolgus CD3 epsilon & CD3 gamma Heterodimer Protein on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

HPLC Data
CD3E&CD3G HPLC.png

The purity of Recombinant Cynomolgus CD3 epsilon & CD3 gamma Heterodimer Protein was greater than 95% as determined by SEC-HPLC.

ELISA data
CD3E&CD3G ELISA.png

Immobilized Cyno CD3 epsilon & CD3 gamma Heterodimer Protein at 0.5ug/ml (100ul/Well). Dose response curve for SP34 with EC50 of 0.15ug/ml determined by ELISA

Background

T-cell surface glycoprotein CD3 epsilon & CD3 gamma chain, also known as CD3E & CD3G , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.

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