400-614-0008

Human B7-H3 Protein


Cat:BH7-HM173

Description

B7-H3.png
Synonyms:

B7H3; B7-H3; CD276 antigen; CD276 molecule; CD276; B7H34Ig-B7-H3; B7-H3B7 homolog 3; Costimulatory molecule

Formulation and Storage

Formulation:

Supplied as 0.22um filtered solution in PBS (pH 7.4).

Storage:

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data

Tris-Bis PAGE
B7-H3 GEL.png

Recombinant B7-H3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

HPLC data
B7-H3 HPLC.png

The purity of B7-H3(Cat. BH7-HM173) is greater than 95% as determined by SEC-HPLC

ELISA data
B7-H3 ELISA.png

Immobilized Human B7-H3 at 0.5ug/ml (100ul/Well).Dose response curve for Anti B7-H3 Ab. with the EC50 of 80.8ng/ml determined by ELISA.

Background

B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma ) production, and cytotoxic T cells induction.

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