400-614-0008

Human Beta Klotho Protein


Cat:KLB-HM101

Description

klotho.png
Synonyms:

betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; klotho beta-like protein; MGC142213

Formulation and Storage

Formulation:

Supplied as 0.22um filtered solution in PBS (pH 7.4).

Storage:

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data

Tris-Bis PAGE
klotho PAGE.png

Recombinant Human Beta Klotho Protein on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

HPLC Data
klotho HPLC.png

The purity of Human Beta Klotho is greater than 95% as determined by SEC-HPLC.

ELISA data
klotho ELISA 1.png

Immobilized Human Klotho at 1ug/ml(100ul/Well). Dose response curve for Anti-Klotho Ab.1 with the EC50 of 0.4ug/ml determined by ELISA.


klotho ELISA 2.png

Immobilized Human Klotho at 2ug/ml(100ul/Well).Dose response curve for Anti-Klotho Ab. 2 with the EC50 of 20.5ng/ml determined by ELISA.


Background

Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases.

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