400-614-0008

Human CD3 epsilon & CD3 delta Heterodimer Protein


Cat:CD3-HM205

Description

T.jpg
Synonyms:

CD3;CD3D;CD3-DELTA;T3D;CD3E

Formulation and Storage

Formulation:

Supplied as 0.22um filtered solution in PBS (pH 7.4).

Storage:

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data

Tris-Bis PAGE
CD3E-3D-GEL.jpg

Recombinant Human CD3 epsilon & CD3 delta Heterodimer Protein on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

HPLC Data
CD3E-3D-HPLC.jpg

The purity of Recombinant Human CD3 epsilon & CD3 delta Heterodimer Protein was greater than 95% as determined by SEC-HPLC.

ELISA data
CD3E-3D-ELISA1.jpg

Immobilized Human CD3E&CD3D,Fc Tag at 0.5ug/ml (100ul/Well). Dose response curve for Anti-CD3E/CD3D Ab1.with the EC50 of 21.69ng/ml determined by ELISA.

CD3E-3D-ELISA2.jpg

Immobilized Human CD3E/CD3D at 0.1ug/ml (100ul/Well). Dose response curve for Anti-CD3E/CD3D Ab2.with the EC50 of 21ng/ml determined by ELISA.

Batch to Batch Consistency
CD3E&CD3D-1.jpg

Immobilized Human CD3E/CD3D,Fc Tag at 1ug/ml(100ul/Well).Dose response curve for Anti-Human CD3E/CD3D Ab.(OKT3) with the EC50 of 28.8/25.5/27.8ng/ml determined by ELISA.

37℃ Stability Test
3E-D-S.jpg

Immobilized Human CD3E/CD3D at 0.1μg/ml(100μl/Well).Dose response curve for Anti-Human CD3E/CD3D Ab.(OKT3) with the EC50 of 23.8/22.6/23.5/22.8ng/ml determined by ELISA.

Background

T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.

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