400-614-0008

Human Siglec-15 Protein


Cat:SIG-HM415

Description

Siglec-15 His.png
Synonyms:

CD33 antigen-like 3 SIGLEC-15; CD33 molecule-like 3; CD33L3; HsT1361; sialic acid binding Ig-like lectin 15; sialic acid-binding Ig-like lectin 15; Siglec15; Siglec-15

Formulation and Storage

Formulation:

Supplied as 0.22um filtered solution in 20mM NaAc-HAc(pH 5.0) .

Storage:

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data

Tris-Bis PAGE
Siglec-15 His gel.png

Recombinant Siglec-15 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

HPLC Data
Siglec-15 His HPLC.png

The purity of Siglec-15  is greater than 95% as determined by SEC-HPLC.

ELISA data
Siglec-15 His ELISA.png

Immobilized human Siglec-15 at 1ug/ml(100ul/well). Dose response curve for Anti-Siglec15 mAb with the EC50 of 127.1ng/ml determined by ELISA

Background

Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates..

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