CD33 antigen-like 3 SIGLEC-15; CD33 molecule-like 3; CD33L3; HsT1361; sialic acid binding Ig-like lectin 15; sialic acid-binding Ig-like lectin 15; Siglec15; Siglec-15
Supplied as 0.22um filtered solution in 20mM NaAc-HAc(pH 5.0) .
The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.
Recombinant Siglec-15 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
The purity of Siglec-15 is greater than 95% as determined by SEC-HPLC.
Immobilized human Siglec-15 at 1ug/ml(100ul/well). Dose response curve for Anti-Siglec15 mAb with the EC50 of 127.1ng/ml determined by ELISA
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates..