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Human HLA-A*0201 WT-1 (RMFPNAPYL) complex Protein


BACKGROUND

Intracellular molecules represent nearly half of the human proteome and provide an untapped reservoir of potential therapeutic targets. Intracellular proteins can be degraded by the proteasome into short, commonly 8–10 amino acid long, peptides that are presented on the cell surface in the context of major histocompatibility complex class I (MHC-I) molecules. T-cell receptor or T-cell receptor mimic (TCRm) antibodie can be used to target peptides bound to major histocompatibility complex class I (MHC-I) molecules on the cell surface.  MHC/antigenic peptide complexes are good tools for antibody or TCR discovery.

APPLICATION

Antibody discovery,TCR discovery:Immunization,Screening,Function Characterization

Binding asssay:ELISA,SPR, BLI

Pharmacokinetic:Quantitative ELISA

PRODUCT LIST

Cat.No.Product NameSpeciesTag
MHC-HM431HLA-A*0201 WT-1 (RMFPNAPYL)HumanHis-Avi
KEY FEATURES

Mammalian expression,Nature Post-translational modification ,High affinity.

  • WT1 RMF gel.png
    Tris-Bis PAGE Data

    Recombinant Human HLA-A*0201 WT-1 (RMFPNAPYL) complex Protein on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

  • WT1 RMF HPLC.png
    HPLC Data

    The purity of Human HLA-A*0201 WT-1 (RMFPNAPYL) complex Protein was greater than 95% as determined by SEC-HPLC.

  • WT1 RMF ELISA.png
    ELISA Data

    Immobilized Human HLA-A*0201 WT-1 (RMFPNAPYL) complex at 2ug/ml(100ul/Well).Dose response curve for Anti-WT1 complex mAb.with the EC50 of 193.9ng/ml determined by ELISA.

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