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Human CD24 Protein


BACKGROUND

The “Don't Eat Me” signal was identified in Weissman’s laboratory in 2009. His team found that nearly all cancer cells express high levels of a molecule called CD47 on their surfaces. They showed that CD47 binds to a protein called SIRPalpha on the surface of macrophages, inhibiting their ability to kill the cancer cells. CD24 Is a “Don't Eat Me” Signal That Promotes Tumor Immune Escape. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

APPLICATION

Antibody discovery:Immunization,Screening,Function Characterization

Binding asssay:ELISA,SPR, BLI

Pharmacokinetic:Quantitative ELISA

PRODUCT LIST

Cat.No.Product NameSpeciesTag
CD2-HM324Human CD24 ProteinHumanmFc
CD2-HM624Human CD24 ProteinHumanLlama IgG2b Fc
CD2-HM224Human CD24 ProteinHumanhFc
SIG-HM210Human Siglec-10 ProteinHumanHis
KEY FEATURES

High Purity, High affinity

  • CD24 mFc HPLC.png
    HPLC Data

    The purity of CD24 mFc is greater than 95% as determined by SEC-HPLC.

  • siglec10 HPLC.png
    HPLC Data

    The purity of Siglec-10  is greater than 95% as determined by SEC-HPLC.

  • CD24 mFc ELISA.png
    ELISA Data

    Immobilized Human CD24, mFc Tag at 0.2ug/ml (100ul/Well).Dose response curve for Anti-CD24 Ab.with the EC50 of 0.19ug/ml determined by ELISA.

  • CD24 Llama Fc ELISA - 副本.png
    ELISA Data

    Immobilized Human CD24, Llama IgG2b Fc Tag at 0.2ug/ml(100ul/Well).Dose response curve for Anti-CD24 Ab.with the EC50 of 0.12ug/ml determined by ELISA..

  • siglec10 ELISA.png
    ELISA Data

    Immobilized human Siglec-10 at 0.5ug/ml(100ul/well). Dose response curve for Anti-Siglec10 with the EC50 of 8.6ng/ml determined by ELISA. 

  • CD24 Fc ELISA.png
    ELISA Data

    Immobilized Human CD24, Fc Tag at 0.5ug/ml (100ul/Well).Dose response curve for biotinylated Anti-CD24 Ab.with the EC50 of 1ug/ml determined by ELISA.

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