The “Don't Eat Me” signal was identified in Weissman’s laboratory in 2009. His team found that nearly all cancer cells express high levels of a molecule called CD47 on their surfaces. They showed that CD47 binds to a protein called SIRPalpha on the surface of macrophages, inhibiting their ability to kill the cancer cells. CD24 Is a “Don't Eat Me” Signal That Promotes Tumor Immune Escape. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
Antibody discovery：Immunization，Screening，Function Characterization
Binding asssay：ELISA，SPR, BLI
Pharmacokinetic：Quantitative ELISA
High Purity, High affinity
The purity of CD24 mFc is greater than 95% as determined by SEC-HPLC.
The purity of Siglec-10 is greater than 95% as determined by SEC-HPLC.
Immobilized Human CD24, mFc Tag at 0.2ug/ml (100ul/Well).Dose response curve for Anti-CD24 Ab.with the EC50 of 0.19ug/ml determined by ELISA.
Immobilized Human CD24, Llama IgG2b Fc Tag at 0.2ug/ml(100ul/Well).Dose response curve for Anti-CD24 Ab.with the EC50 of 0.12ug/ml determined by ELISA..
Immobilized human Siglec-10 at 0.5ug/ml(100ul/well). Dose response curve for Anti-Siglec10 with the EC50 of 8.6ng/ml determined by ELISA.
Immobilized Human CD24, Fc Tag at 0.5ug/ml (100ul/Well).Dose response curve for biotinylated Anti-CD24 Ab.with the EC50 of 1ug/ml determined by ELISA.
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