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Human 4-1BB Ligand/TNFSF9 trimer Protein


Cat:BBL-HM241

Description

4-1BBL.png
Synonyms:

41BB Ligand; 4-1BB Ligand; 4-1BBL; 4-1BB-L; CD137L; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; TNFSF9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand superfamily member 9

Formulation and Storage

Formulation:

Supplied as 0.22um filtered solution in PBS (pH 7.4).

Storage:

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data

Tris-Bis PAGE
4-1BBL gel.png

Recombinant 4-1BB Ligand on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

ELISA data
KT133-ELISA.jpg

Immobilized Human 4-1BB,His Tag (Cat.BB4-HM141) at 0.5ug/ml(100ul/Well). Dose response curve for Human 4-1BBL,Fc Tag (Cat.BBL-HM241) with the EC50 of 0.24ug/ml determined by ELISA.

Background

The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.

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