617-806-6359

Human Claudin 18.2 Protein


Cat:CLD-HE1822

Description

18.2-T.jpg
Synonyms:

CLDN18, CLDN18.2, Claudin-18.2

Formulation and Storage

Formulation:

Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.           

Reconstitution:

Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. Don't centrifuge tubes after reconstitution.

Storage:

The product should be stored at -70℃ or -20℃. Please do not repeated freeze-thaw cycles.

Assay Data

SEC-HPLC
VLP-HPLC.jpg

Claudin 18.2 related protein purity is more than 95% by HPLC. 

ELISA data
VLP-ELISA.jpg

Immobilized Claudin18.2 at 5ug/ml (100ul/well), which can bind recombinant Claudin 18.2 antibody IMAB362, with the EC50 of 6.26ug/ml determined by ELISA. 

Background

Claudin18(CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants,CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

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