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Human ANGPTL2/Angiopoietin-like 2 Protein

Product Info
Source

Recombinant Human ANGPTL2/Angiopoietin-like 2 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Thr260-His493.[Accession | Q9UKU9-1]

Molecular Weight

The protein has a predicted MW of 30.1 kDa. Due to glycosylation, the protein migrates to 25-35 kDa based on Tris-Bis PAGE result.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC

Formulation

Supplied as 0.22μm filtered solution in PBS (pH 7.4).

Storage

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data
Tris-Bis PAGE

Human ANGPTL2/Angiopoietin-like 2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human ANGPTL2/Angiopoietin-like 2 is greater than 95% as determined by SEC-HPLC.

SPR Data

Human LILRB2 captured on Protein A chip, can bind Human ANGPTL2/Angiopoietin-like 2, His tag with an affinity constant of 0.14nM as determined in a SPR assay (Biacore T200).

Background

Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.

Synonyms

Angiopoietin-related protein 2;Angiopoietin-like protein 2;ANGPTL2;ARP2

References

(1) Thorin-Trescases N, Thorin E. High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation. Oxid Med Cell Longev. 2017;2017:1096385. doi: 10.1155/2017/1096385. Epub 2017 Aug 24. PMID: 29138671; PMCID: PMC5613648.

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