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Cynomolgus BAFFR/TNFRSF13C Protein

Product Info
Source

Recombinant Cynomolgus BAFFR/TNFRSF13C Protein is expressed from Expi293 with His tag at the C-terminal. It contains Ser7-Gly76.[Accession | A0A2K5V1K1]

Molecular Weight

The protein has a predicted MW of 7.7 kDa. Due to glycosylation, the protein migrates to 13-25 kDa based on Tris-Bis PAGE result.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by Tris-Bis PAGE

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.

Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage

The product should be stored at -70℃ or -20℃.

Assay Data
Tris-Bis PAGE

Cynomolgus BAFFR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

ELISA Data

Immobilized Cynomolgus BAFFR, His Tag at 1μg/ml (100μl/Well) on plate.Dose response curve for Anti-BAFFR Ab., hFc Tag with the EC50 of 11.1ng/ml determined by ELISA.

Background

BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA / TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.

Synonyms

CD268;BAFF R; BAFFR; BR3; TNFRSF13C

References

(1)Tin K , Peng C , Christopher T , et al. BAFF Receptor mAb Treatment Ameliorates Development and Progression of Atherosclerosis in Hyperlipidemic ApoE?/? Mice[J]. PLoS ONE, 2013, 8(4):e60430-.

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