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Human BCMA/TNFRSF17 Protein

Product Info
Source

Recombinant Human BCMA/TNFRSF17 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Met1-Ala54.[Accession | Q02223]

Molecular Weight

The protein has a predicted MW of 8.9 kDa. Due to glycosylation, the protein migrates to 12 kDa and 15-17 kDa based on Tris-Bis PAGE result.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by Tris-Bis PAGE

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.

Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage

The product should be stored at -70℃ or -20℃.

Assay Data
Tris-Bis PAGE

Human BCMA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human BCMA/TNFRSF17 Protein is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human BCMA at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-BCMA Antibody, hFc Tag with the EC50 of 10ng/ml determined by ELISA.

Batch to Batch Consistency

Immobilized Human BCMA at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-BCMA Antibody, hFc Tag with the EC50 of 11/10/9.8ng/ml determined by ELISA.

Background

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).

Synonyms

CD269 antigen; CD269; TNFRSF17; B cell maturation antigen; B-cell maturation protein; BCMA; BCMA tumor necrosis factor receptor superfamily member 17; BCMB-cell maturation factor; tumor necrosis factor receptor superfamily, member 17

References

(1)Bossen C , Schneider P . BAFF, APRIL and their receptors: Structure, function and signaling[J]. Seminars in Immunology, 2006, 18(5):0-275.D

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