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Human CD24 Protein-VLP

Product Info
Source

Recombinant Human CD24 Protein-VLP is expressed from Expi293. It contains Ser27-Gly59.[Accession | P25063]

Molecular Weight

The Human CD24 Protein has a predicted MW of 5.0 kDa.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by SEC-HPLC

Formulation

Supplied as 0.22μm filtered solution in PBS (pH 7.4).

Storage

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data
SEC-HPLC

The purity of Human CD24 Protein-VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human CD24 VLP at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CD24 Antibody, hFc Tag with the EC50 of 21.4ng/ml determined by ELISA.

Background

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers.

Synonyms

CD 24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24; CD24A; CD24Asignal transducer CD24; FLJ22950; FLJ43543; MGC75043; Small cell lung carcinoma cluster 4 antigen

References

(1)Barkal AA, et al.CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.Nature. 2019 Jul 31. doi: 10.1038/s41586-019-1456-0.D

(2)Sun F, Wang T, Jiang J, et al. Engineering a high-affinity humanized anti-CD24 antibody to target hepatocellular carcinoma by a novel CDR grafting design[J]. Oncotarget, 2017, 8(31):51238-51252.

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