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Human Claudin 18.2 Protein-VLP

Product Info
Source

Full length Human Claudin 18.2 Protein-VLP is expressed from Expi293. It contains Met1-Val261 .[Accession | P56856-2]

Molecular Weight

The Human Claudin 18.2 Protein has a predicted MW of 29 kDa.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by HPLC

Formulation

Supplied as 0.22μm filtered solution in PBS (pH 7.4).Notice: If you need it for immunization, Do Not use any adjuvant.

Storage

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data
SEC-HPLC

The purity of Human Claudin 18.2 Protein-VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human Claudin18.2 VLP on the plate. Dose response curve for Anti-Claudin18.2 Antibody, hFc Tag with the EC50 of 10.1ng/ml determined by ELISA.

SPR Data

Human Claudin 18.2 Protein-VLP, Amine coupling on CM5 Chip, Anti-Claudin18.2 Antibody as analyte; The affinity constant of 3.06nM as determined in SPR assay (Biacore T200).

Background

Claudin18(CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants,CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

Synonyms

CLDN18;CLDN18.2;Claudin-18.2

References

(1)Singh P , Toom S , Huang Y . Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.

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