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Human GPRC5D Protein-VLP

Product Info
Source

Recombinant Human GPRC5D Protein-VLP is expressed from Expi293. It contains Met1-Val345.[Accession | Q9NZD1]

Molecular Weight

The Human GPRC5D membrane Protein has a predicted MW of 39.6 kDa.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by SEC-HPLC

Formulation

Supplied as 0.22μm filtered solution in PBS (pH 7.4).Notice: If you need it for immunization, do not use any adjuvant.

Storage

The product should be stored at -70℃. Please do not repeated freeze-thaw cycles.

Assay Data
SEC-HPLC

The purity of Human GPRC5D Protein-VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human GPRC5D VLP at 5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 11.8ng/ml determined by ELISA.

Background

Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.

Synonyms

G-protein coupled receptor family C group 5 member D;GPRC5D

References

(1) Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, De Larrea CF, Olson E, Peguero E, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Wendel HG, Riviere I, Liu C, Sather B, Brentjens RJ. GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells. Sci Transl Med. 2019 Mar 27;11(485):eaau7746. doi: 10.1126/scitranslmed.aau7746. PMID: 30918115; PMCID: PMC7508042.

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