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Human LILRA6/CD85b/ILT8 Protein

Product Info
Source

Recombinant Human LILRA6/CD85b/ILT8 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Gly24-Asn447.[Accession | Q6PI73]

Molecular Weight

The protein has a predicted MW of 49.2 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by Tris-Bis PAGE
> 95% as determined by SEC-HPLC

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.

Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage

The product should be stored at -70℃ or -20℃.

Assay Data
Tris-Bis PAGE

Human LILRA6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human LILRA6 is greater than 95% as determined by SEC-HPLC.

Background

The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

Synonyms

7M1; CD85b; ILT8; LILRA6; Pira3;Leukocyte Ig-like receptor;Leukocyte immunoglobulin-like receptor subfamily A member 6

References

(1)Jones D C , Hewitt C R A , María R López-Álvarez, et al. Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8 - associated ligand on necrotic glandular epithelial cells[J]. Oncotarget, 2016, 7(13).

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