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Human LILRB5/CD85c/LIR-8 Protein

Product Info
Source

Recombinant Human LILRB5/CD85c/LIR-8 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Arg18-His456.[Accession | O75023]

Molecular Weight

The protein has a predicted MW of 49.9 kDa. Due to glycosylation, the protein migrates to 67-72 kDa based on Tris-Bis PAGE result.

Endotoxin

Less than 1EU per μg by the LAL method.

Purity

> 95% as determined by Tris-Bis PAGE

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.

Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage

The product should be stored at -70℃ or -20℃.

Assay Data
Tris-Bis PAGE

Human LILRB5 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human LILRB5 is greater than 95% as determined by SEC-HPLC.

Background

LILRB5, also known as CD85c andLIR-8, belongs to a family of transmembrane glycoproteins that negatively regulate immune cell activation. Mature human LIR-8 consists of a 435 amino acid (aa) extracellular domain with four Ig-like domains, a 21 aa transmembrane segment, and a 111 aa cytoplasmic domain with two immunoreceptor tyrosine-based inhibitory motifs (ITIM). LILRB5 may act as receptor for class I MHC antigens.

Synonyms

CD85 antigen-like family member C; CD85c antigen; CD85c; Leukocyte immunoglobulin-like receptor 8; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains); LILRB5; LIR8; LIR-8; LIR8CD85C; LIR-8leukocyte immunoglobulin-like receptor subfamily B member 5; member 5

References

(1)Hogan L E , Jones D C , Allen R L . Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure[J]. Scientific Reports, 2016, 6(1):21780.

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