CAR-T Cell Therapy Targets

Chimeric antigen receptor-modified T (CAR-T) cell therapy is a new form of immunotherapy which have achieved significant success in the treatment of several hematological malignancies.
The idea of CAR-T therapy is programming the immune system to attack cancer. In brief, patient's T cells were isolated and genetically engineered to express a chimeric antigen receptor (CAR) which recognizes a specific tumor-associated antigen (TAA) such as CD19, a cell surface protein that is uniformly and strongly expressed on malignant B cells. Two newly FDA-approved drugs specific for CD19, KymriahTM and YescartaTM indicate the importance of a proper TAA in the research on CAR T-cell therapy.
Based on our featured SAMSTM platform, Kactus has developed a series of recombinant proteins covering multiple CAR-T cell therapy targets, including some difficult-to-express proteins such as CD19 and BCMA.
Product List
Cat. No. Protein Name Species Tag Exp. System
CD1-HM119F FITC-compatible CD19 Protein Human C-His Expi293 Inquiry Now
BH7-HM173 Human B7-H3/CD276 Protein Human C-His Expi293 Inquiry Now
BCM-HM117 Human BCMA/TNFRSF17 Protein Human C-His-Avi Expi293 Inquiry Now
IL3-HM1RA Human IL-3 R alpha/CD123 Protein Human C-His Expi293 Inquiry Now
SIG-HM122 Human Siglec-2/CD22 Protein Human C-His Expi293 Inquiry Now
CD3-HM430 Human CD30/TNFRSF8 Protein Human C-His-Avi Expi293 Inquiry Now
CD3-HM433 Human Siglec-3/CD33 Protein Human C-His-Avi Expi293 Inquiry Now
CD3-HM138 Human CD38 Protein Human C-His Expi293 Inquiry Now
CD4-HM401 Human CD4/LEU3 Protein Human C-His-Avi Expi293 Inquiry Now
CD7-HM401 Human CD7 Protein Human C-His-Avi Expi293 Inquiry Now
CAM-HM405 Human CEACAM5/CD66e Protein Human C-His-Avi Expi293 Inquiry Now
EG8-HM154 Human EGFR VIII Protein Human C-His-Avi Expi293 Inquiry Now
EGF-HM401 Human EGFR/HER1 Protein Human C-His-Avi Expi293 Inquiry Now
VGF-HM4R2 Human KDR/VEGFR2 Protein Human C-His-Avi Expi293 Inquiry Now
CAM-HM1EP Human EpCAM/Trop1 Protein Human C-His Expi293 Inquiry Now
FAP-HM101 Human FAP Protein Human N-His Expi293 Inquiry Now
FOL-HM4R1 Human FOLR1 Protein Human C-His-Avi Expi293 Inquiry Now
GPC-HM131 Human GPC3/Glypican 3 Protein Human C-His Expi293 Inquiry Now
HER-HM402 Human ErbB2/Her2 Protein Human C-His-Avi Expi293 Inquiry Now
HER-HM403 Human ErbB3/Her3 Protein Human C-His-Avi Expi293 Inquiry Now
MSL-HM480 Human Mesothelin/MSLN Protein Human C-His-Avi Expi293 Inquiry Now
NEC-HM404 Human Nectin-4 Protein Human C-His-Avi Expi293 Inquiry Now
NKG-HM42D Human NKG2D/CD314 Protein Human N-His-Avi Expi293 Inquiry Now
PSM-HM110 Human PSMA/FOLH1 Protein Human N-His Expi293 Inquiry Now
ROR-HM401 Human ROR1 Protein Human C-His-Avi Expi293 Inquiry Now
SMF-HM407 Human SLAMF7/CRACC/CD319 Protein Human C-His-Avi Expi293 Inquiry Now
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