Human LY6G6D Protein (LYD-HM16D)

Express System: HEK293
Product Tag: C-His-Strep-II
Purity: > 95% as determined by Tris-Bis PAGE
Activity: Immobilized Human LY6G6D, His Tag at 0.2ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 2.1ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Asn20-Ser104

Catalog: LYD-HM16D

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Product Description	Recombinant Human LY6G6D Protein is expressed from HEK293 with His tag and Strep-II tag at the C-Terminus.It contains Asn20-Ser104.
Product Background	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.
Product Category	Recombinant Protein

Target	LY6G6D
Gene/Protein ID	O95868
Species	Human
Exact Sequence	Asn20-Ser104
Molecular Weight	The protein has a predicted MW of 12.33 kDa. Due to glycosylation, the protein migrates to 15-20 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human LY6G6D, His Tag at 0.2ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 2.1ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Strep-II
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human LY6G6D, His Tag at 0.2ug/ml (100ul/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 2.1ng/ml determined by ELISA.
	Human LY6G6D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.