Name: PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein (MHC-HM421TP)
Brand: KactusBio
SKU: MHC-HM421TP-100UG
Price: 1150.0 USD
Availability: InStock

PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein (MHC-HM421TP)

Immobilized PE-labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 12.8ng/ml determined by ELISA (QC Test).

Express System: HEK293
Product Tag: C-His-Avi
Activity: Immobilized PE-labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 12.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Gly25-Thr305 (HLA-A*11:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide

Catalog #MHC-HM421TP

Size

100UG

500UG

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Product Description	Recombinant PE-Labeled Human HLA-A11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-labeled Human HLA-A11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin.; It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide.
Product Background	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Product Category	Recombinant Protein / Antibody discovery / MHC

Protein	HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer
Synonyms	MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
MHC Form	Tetramer
Allele	HLA-A*11:01
Accession	AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGAVGVGK
Species	Human
Biotinylated	no
Amino Acid Range	Gly25-Thr305 (HLA-A*11:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide
Activity	Immobilized PE-labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 12.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Avi
Fluorophore	PE
Expression System	HEK293
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS, 0.2% BSA (pH 7.4).
Stability And Storage	Valid for 6 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Immobilized PE-labeled Human HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 12.8ng/ml determined by ELISA (QC Test).

Additional Information

Learn More: MHC Collection Learn More: Peptide-ready MHC Protocol: MHC Staining Case Study: Peptide-ready MHC for TCR Staining Poster: Engineering MHCs as Versatile Reagents Publication: Use of our Peptide-Ready MHCs in CAR-T Cell Research Product Brochure