Cynomolgus GPRC5D Protein-VLP (GPR-CM05P)

  • Express System: HEK293
  • Purity: > 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus GPRC5D VLP (100ul/well) at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 6.91ug/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Met1-Cys300

Catalog: GPR-CM05P

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Product Description Recombinant Cynomolgus GPRC5D Protein-VLP is expressed from HEK293.It contains Met1-Cys300.

Product Background

 Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.

Product Category

 Recombinant Protein

Target

 GPRC5D VLP

Gene/Protein ID

 A0A2K5W6I7

Species

 Cynomolgus

Exact Sequence

 Met1-Cys300
Molecular Weight The target protein has a predicted MW of 35.10 kDa.

Activity

 Immobilized Cynomolgus GPRC5D VLP (100ul/well) at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 6.91ug/ml determined by ELISA. See testing image for detail.

Express System

 HEK293
Purity > 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Cynomolgus GPRC5D VLP (100ul/well) at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 6.91ug/ml determined by ELISA.
The purity of Cynomolgus GPRC5D VLP is greater than 95% as determined by SEC-HPLC.

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