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Rethinking Refolding: The Case for Mammalian-Expressed Single-Chain Trimer MHCs

For years, recombinant major histocompatibility complexes (MHCs) have been expressed in bacterial systems with in vitro refolding. While this preserves the native MHC sequence...

August 20, 2024

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VLP Antibody Discover

October 2, 2024

4 min read

How VLPs are unlocking the next generation of antibody therapeutics for challenging transmembrane proteins Transmembrane proteins play crucial roles in...

Rethinking Refolding: The Case for Mammalian-Expressed Single-Chain Trimer MHCs

September 18, 2024

5 min read

For years, recombinant major histocompatibility complexes (MHCs) have been expressed in bacterial systems with in vitro refolding. While this preserves...

Virus-Like Particles (VLPs): Understanding their Structure, Expression, and Role in Immune Response

August 28, 2024

7 min read

What are virus-like particles (VLPs)? Virus-like particles (VLPs) are nanoparticle structures (50-300nm diameter) that mimic the organization and conformation of...

Neoantigen-Based Immunotherapy: Unveiling Disease-Specific Targets

August 20, 2024

3 min read

Introducing Neoantigen-Based Immunotherapy Neoantigen-based immunotherapy is revolutionizing cancer treatment by focusing on neoantigens—unique proteins formed by mutations in cancer cells....

AccuBase™: Base Editing Enzyme Advancing NK Cell Cancer Therapy

July 31, 2024

3 min read

KACTUS, the strategic partner of Base Therapeutics, is the exclusive supplier of GMP-grade AccuBase™, the world’s first “off-the-shelf” cytosine base...

IND Approval for Solid Tumor Therapy Using KACTUS Cas9 Enzyme

July 24, 2024

4 min read

In a groundbreaking development for the biotech industry, KACTUS's GMP-grade Cas9 has critically helped Yizun Bio secure IND clearance for a universal...

The Ideal Choice for Low dsRNA: MaxPure™ T7 RNA Polymerase

July 16, 2024

7 min read

Exciting news of mRNA vaccine research against monkeypox has been coming out since the beginning of 2024: February 15, the...

Inflammatory Target: TSLP

July 2, 2024

4 min read

Thymic Stromal Lymphopoietin (TSLP), is a pleiotropic cytokine of the IL-2 family, closely related to IL-7, playing a significant role...

Gene Editing Drugs from the EMA Review Perspective

June 25, 2024

5 min read

Casgevy, the world's first drug based on CRISPR/Cas9 gene-editing technology, was approved for market release at the end of 2023,...

New Momentum for Integrin Drugs: Integrin αvβ6

June 19, 2024

4 min read

Function and Signaling Pathway of Integrin αvβ6 Integrin αvβ6 (hereinafter referred to as αvβ6) belongs to the integrin family of...

The Key to Muscle Regulation: GDF-8

June 13, 2024

4 min read

Peptide-based weight loss drugs have swept the globe, but the side effects of these drugs are also significant. A substantial...

Fat Loss and Muscle Gain: Targeting the Activin Signaling Pathway

May 30, 2024

4 min read

In July 2023, Eli Lilly made a nearly $2 billion bet on Versanis' ActRII inhibitor, Bimagrumab, citing its ability to...

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