News & Articles

FEATURED ARTICLE

KACTUS GMP-Grade Cas9 Enzyme supports manufacturing and FDA clearance of UCAR-T cell therapy drug products

KACTUS is excited to share that our GMP-Grade Cas9 enzyme is serving as a critical manufacturing raw material for an investigational new drug (IND) developed by Bioheng Therapeutics. Bioheng’s innovative UCART cell product received IND clearance by the U.S. Food and Drug Administration (FDA) on March 1, 2025 [1]. This approval marks...

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Cracking KRAS: How TCR-T and TCR-Mimic Antibodies Are Changing KRAS Mutant Cancers

March 18, 2025

9 min read

Introduction Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most frequently mutated oncogenes in human cancer​ [1]. Mutations in...

Optimizing Large-scale Circular RNA Production Process with KACTUS Engineered RNase R

March 13, 2025

9 min read

Circular RNA: A type of therapeutic drug modality.  Circular RNA (circRNA) is a class of covalently closed, circular non-coding RNA...

Breaking News: KACTUS GMP-Grade Cas9 Powers Bioheng’s Breakthrough IND Clearance for Next-Gen UCAR-T Therapy

March 5, 2025

4 min read

KACTUS is thrilled to announce that our GMP-Grade Cas9 enzyme is playing a pivotal role in the development of Bioheng Therapeutics'...

NPR1: Major Drug Target for Heart Failure

February 25, 2025

5 min read

Global Rise of Heart Failure Heart failure (HF) is a severe clinical syndrome with an estimated global prevalence of 1-3%...

Effective Serratia marcescens Nuclease for DNA & RNA Removal: MaxNuclease™

February 21, 2025

3 min read

Nucleic acid removal is an essential step in biologics production workflows. Our MaxNuclease™ enzyme is a non-specific endonuclease from Serratia...

MASP2 Antibody Successful in Phase III Clinical Trial

February 10, 2025

5 min read

On December 19, 2024, Omeros announced that its pivotal Phase 3 clinical trial of the MASP2 antibody Narsoplimab (OMS721) in...

Case Study: KACTUS T7 RNA Polymerase Enzyme Demonstrates Superior Performance in Independent Study

February 7, 2025

4 min read

Background The production of high-quality mRNA is critical for a wide range of applications, including gene therapy, vaccine development, and...

Immunotherapy Target: CD19 Antigen

February 4, 2025

7 min read

CD19 remains a hot target in immunotherapy, driving innovation across a range of diseases. This is evidenced by recent approvals...

Panorama of CRISPR Gene Editing Clinical Applications: 2024 Review

January 31, 2025

8 min read

The approval of Casgevy in the UK in December 2023, the first CRISPR gene editing drug, marked the era of...

Case Review: Exploring domain proteins in antibody development

January 22, 2025

7 min read

Domain Antigens for Antibody Discovery & Screening The antibody drug development underwent rapid progress over the past decade, with almost...

Emerging New Therapeutic Targets for Obesity

January 14, 2025

7 min read

Obesity is increasingly undermining human health. Obesity, a chronic metabolic disease, has significantly impacted the health and quality of life...

Targeting Obesity: GLP-1R/GIPR, GDF8 Leading the Way

December 10, 2024

7 min read

Rising Obesity Rates: A Global Threat Obesity, a chronic metabolic disease, has significantly impacted the health and quality of life...

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