Cynomolgus IL-3 R alpha/CD123 Protein (IL3-CM1RA)
Catalog: IL3-CM1RA
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| Product Description | Recombinant Cynomolgus IL-3 R alpha/CD123 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg18-Arg302. |
Product Background |
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. |
Product Category |
Recombinant Protein |
Target |
IL-3 R alpha/CD123 |
| Synonyms | CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha |
Gene/Protein ID |
G8F3K3-1 |
Species |
Cynomolgus |
Exact Sequence |
Arg18-Arg302 |
| Molecular Weight | The protein has a predicted MW of 33.9 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result. |
Activity |
The affinity constant of 0.46 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Human IL-3, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-3 R alpha, His Tag with an affinity constant of 0.46 uM as determined in SPR assay (Biacore T200) (QC Test). |
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Cynomolgus IL-3 R alpha, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-3, His Tag with an affinity constant of 1.30 nM as determined in SPR assay (Biacore T200). |
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The purity of Cynomolgus IL-3 R alpha is greater than 95% as determined by SEC-HPLC. |
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Cynomolgus IL-3 R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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