Human Activin RIIA/ACVR2A-Protein (ARA-HM22A)
Catalog: ARA-HM22A
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Product Description | Recombinant Human Activin RIIA/ACVR2A-Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ala20-Pro135. |
Product Background |
Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer. |
Product Category |
Recombinant Protein |
Target |
Activin RIIA/ACVR2A |
Gene/Protein ID |
P27037-1 |
Species |
Human |
Exact Sequence |
Ala20-Pro135 |
Molecular Weight | The protein has a predicted MW of W 39.35 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIA, hFc Tag with the EC50 of 2.1ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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