• Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Asp1-Ala144
Catalog #TRB-RM1C2
Price
Regular price $000
Regular price Sale price $000
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Size
Avantor VWR Fisher Scientific

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Rhesus macaque TRBC2 Protein (TRB-RM1C2) Summary

Product Description

 Recombinant Rhesus macaque TRBC2 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Asp1-Ala144.

Product Background

 T cell receptor β-chain constant (TRBC) is a promising class of cancer targets consisting of two highly homologous proteins, TRBC1 and TRBC2. While each TCRα/β carries either TRBC1 or TRBC2 in a mutually exclusive manner, the normal T cell population comprises a mixture of individual cells, either expressing TRBC1 or TRBC2. However, the cancer T-cell population exclusively expresses either TRBC1 or TRBC2. Using antibodies to specifically target TRBC1 (TCRαβ1) or TRBC2 (TCRαβ2) (in the case of a TRBC1+ T cell malignancy or the case of a TRBC2+ malignancy, respectively) has been proposed to be a strategy to eradicate all cells of malignant cancer.

TRBC2 Specifications

Protein
 TRBC2
Synonyms
 T cell receptor beta constant 2
Accession
Species
 Rhesus macaque
Biotinylated
 no
Amino Acid Range
 Asp1-Ala144
Molecular Weight
 The protein has a predicted MW of 17.81 kDa. Due to glycosylation, the protein migrates to 18-25 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His
Fluorophore
 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Rhesus macaque TRBC2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Rhesus macaque TRBC2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Rhesus macaque TRBC2 is greater than 95% as determined by SEC-HPLC. The purity of Rhesus macaque TRBC2 is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...