Comprehensive collection of

GMP-grade enzymes for mRNA synthesis

Accelerating commercial-scale mRNA manufacturing

Kactus develops the following enzymes to meet the highest quality requirements for commercial-scale mRNA transcription and modification. Products are manufactured to the GMP standards and are carefully validated and tested for batch consistency. Regulatory support documents are available for filing and approval purposes.

Vaccinia Capping Enzyme– System for enzymatic capping based on the Vaccinia virus Capping Enzyme

mRNA Cap 2′-O-Methyltransferase– Adds a methyl group at the 2′-O position of the first nucleotide adjacent to the cap structure at the 5´ end of the RNA

BsaI–  Restriction enzyme used to linearize plasmid DNA for mRNA therapeutics

T7 RNA Polymerase– RNA Polymerase used for in vitro mRNA synthesis, and is highly specific for the T7 phage promoter

Pyrophosphatase, Inorganic– Inorganic pyrophosphatase (PPase) catalyzes the hydrolysis of inorganic pyrophosphate to form orthophosphate

DNase I (RNase-free)– DNA-specific endonuclease used for removal of contaminating genomic DNA from RNA samples and degradation of DNA templates in transcription reactions

Murine RNase Inhibitor– RNase Inhibitor, Murine, specifically inhibits RNases A, B and C