Recombinant CRISPR Cas9, GMP-Grade

KACTUS offers GMP-Grade CRISPR Cas9 enzymes suitable for manufacturing of cell & gene therapeutics.

CRISPR-Cas9 is derived from an immune defense system used by bacteria to attach to and cleave viral RNA. Scientists have since harnessed the CRISPR-Cas9 system to perform genome editing in mammalian cells.

Recombinant Streptococcus pyogenes Cas9 nuclease, purified from E.coli, is a powerful tool for genome editing. The nuclease can also be applied to the field of molecular diagnosis. 

Our version has undergone codon optimization, nuclear localization signal (NLS) design, and optimization of E. coli expression and purification.

Based on KACTUS’s proprietary Structure Aided Design and Multiplex Screening SAMS™ platform, we have successfully developed a highly active Cas9 protein through a series of steps such as protein structure analysis, expression process screening, purification process optimization, and formulation development. Our Cas9 protein works well with T-cells, stem cells, etc.


KACTUS offers GMP-grade CRISPR Cas9 enzyme, suitable for manufacturing of cell and gene therapeutics. We have strict quality control specifications to ensure the product quality meets your needs with high batch-to-batch consistency. We also offer product customization and scientific design support. Read more about our GMP-grade products.