Construct design, expression, and purification from µg to kg.
We specialize in providing customized solutions for recombinant protein production. Whether you require modifications to existing proteins or entirely novel constructs, we are committed to delivering active, efficient, and scalable results. Our recombinant protein production experience along with our proprietary SAMS™ platform will ensure your product has the optimal configuration and expression conditions for bioactivity and purity.
How it works
Seamless collaboration & transparent solutions
Our expert team will collaborate with you to ensure the final product meets your specific criteria. We strive to make your experience seamless and productive, which is why we're transparent in turnaround times, costs, and success probabilities. Partner with us to advance your scientific discoveries and bioprocessing projects with reliability and ease.
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Custom Protein Expression Workflow
Our custom protein services are designed to provide communication, transparency, and quality. This workflow ensures that your custom protein needs are met according to your standards.
- Initial discussion
- Protein development and expression
- Quality Control and Quality Assurance
Customization Types
Customize a Catalog Protein
Our team can modify parameters such as tags, biotinylation, and fluorescent labels, to ensure the product aligns with your precise requirements. This option provides a cost-effective and efficient solution by leveraging our established product base while meeting your unique specifications.
Create a Novel Protein
For more specialized needs, we offer expression of unique protein constructs. Our research team will design, express, and purify proteins of interest, with your tags, cleavage sites, buffers, concentrations, quantity, etc. This service ensures you receive a customized solution that drives your research forward and supports groundbreaking discoveries.
Service Details
What information is needed to start?
To get started, our scientific team will work with you to review all necessary conditions and requirements. We'll discuss details such as exact sequence, tags, cleavage sites, buffers, concentrations, yields, quantity and any other relevant information. This ensures we understand your specific needs and can deliver precisely what you're looking for. Simply provide us with as many project details as you can, and we'll guide you through the rest.
What is the typical turnaround time?
The majority of our custom protein expression can be accomplished in 6-8 weeks. Various factors such as quantity, difficulty of expression, and bioactivity testing requirements, can increase or decrease this time. Request a quote for your specific requirements and we'll provide a more detailed timeline.
What expression systems are offered?
Mammalian Expression
We offer large-scale production of HEK293 or CHO-expressed recombinant proteins. Our optimized expression system ensures reliability for intracellular, secreted, and transmembrane proteins.
E. Coli Expression
Our bacterial expression systems deliver reliable and reproducible production and purification of recombinant proteins at large-scale. Additionally, our E. coli expression system is cGMP certified and with bioreactors up to 1000L. Learn more about our GMP production.
Insect Expression
Insect cell expression systems offer many post-translational modifications similar to mammalian cell expression and offer high protein yields. This method brings versatility and adaptability to your protein expression.
Yeast Expression
Yeast expression systems offer high product yield and scalability, with easy genetic manipulation to produce proteins with desired properties not achievable in bacterial cells.
Explore our most popular custom solutions
Soluble TCR Expression
Soluble TCR Expression services with engineering, and optimization of various formats of TCRs.
SPR Analysis Services
Characterization of biomolecular interactions using Surface Plasmon Resonance technology.
Solute Carrier Proteins
Custom solute carrier protein expression services displayed on VLPs or Nanodiscs.
Why choose KACTUS?
Structure Optimization
Optimized protein configuration to enhance specificity, sensitivity, and yield.
Purity & Bioactivity
Analyzed for purity and bioactivity to ensure successful application.
Large Batch
Large-scale production batches with batch-to-batch consistency.
Request Custom Protein Expression Services
Learn more about KACTUS
TECHNOLOGY PLATFORM
SAMS™ Protein Engineering Platform
Our proprietary protein engineering platform uses bioinformatics and 3D modeling combined with in vitro expression condition testing to optimize protein configuration.
PROTEIN QUALITY
Quality Control
We offer strict quality control testing on custom proteins including SPR, ELISA, purity, and endotoxin. Let us know the specific quality requirements for your project.
OUR COMPANY
About Us
We are a recombinant protein and enzyme company known for tackling the most difficult-to-express proteins. We focus on unmet protein requirements in drug discovery and beyond. Our values our grounded in quality products and quality service.
60 Hickory Drive
Waltham, MA 02451
United States
Custom Recombinant Protein Expression Services | KACTUS