Structure Based Antigen Design

A rational high-throughput strategy for drug discovery

Recombinant antigen production has been gaining increasing focus as antibody therapeutics now represent the core of the human medical biotechnology industry. The most common challenges in recombinant antigen production include membrane protein antigen production, recombinant antigen immunogenicity, antibody affinity, production batch-to-batch consistency, and production time consuming and cost-efficiency.

To address these issues, scientists at KactusBio have creatively designed a high-throughput protein expression and purification screening system named SAMS (Structure Aided Design and Multiplex Screening).

Structure-based rational design is the essential part of protein engineering, as protein secondary and tertiary structures directly impact protein expression, folding, and function. In addition to common considerations like secretive signal peptide, fusion tag, and codon optimization, scientists at KactusBio perform comprehensive structural informatics, including 3D modeling into protein designs, making SAMS platform both powerful and unique to the industry.

Advantages of products from SAMS Platform

-Individual structure-based antigen design;

-Mimic native antigen confirmation display;

-Optimized expression: high purity & high yield;

-Enhanced immunogenicity;

-High bioactivity;

-Low endotoxin;

-Great protein stability;

-High degree of batch-to-batch consistency.

Our products and services are used worldwide for diverse applications, including basic research, drug discovery, diagnostic study,  antibody production quality control for batch release,  and much more. Based on the SAMS Platform, multiple challenge antigens have been produced, such as the first full-length Claudin 18.2 in the world, and our products have been highly recognized by pharmaceutical customers.