Reliable and bioactive commercial proteins are fundamental to successful and timely drug development.

SAMS

Structure Aided Design & Multiplex Screening

Researchers face common challenges when using recombinant proteins including:

→ Membrane protein antigen production
→ Recombinant antigen immunogenicity
→ Antibody affinity
→ Batch-to-batch consistency
→ Production time & production cost

SAMS (Structure Aided Design and Multiplex Screening) is our high-throughput protein expression and purification screening system.

The structural hierarchy is the overarching list of variables that will affect protein structure and function.

Unmet needs for commercial proteins are identified via literature and database searches. We then use bioinformatics and structural analysis to design a variety of protein sequences/structures based on variables from the structural hierarchy. 

Integrity, signal peptide, codons, etc. are analyzed using structural informatics and 3D modeling to determine how they will influence all four levels of protein structure. 

The optimal protein configuration is identified from large search spaces of protein configurations and expression conditions. We prioritize natural protein configuration, yield, and bioactivity. 

Protein designs are tested for bioactivity in multiple cell types/settings. Because we ensure protein function in multiple settings, you can be confident that the protein you purchase will work for your application.

Advantages of SAMS Platform

Success with SAMS

Our products are used worldwide for diverse applications, including basic research, drug discovery, diagnostic study, antibody production, quality control testing, and more. Through the SAMS platform, we have already produced multiple challenging proteins, including the first ever full-length Claudin 18.2 protein.