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Human LRP2 (1025-1349) Protein (LRP-HM622) Summary
Product Description |
Recombinant Human LRP2 (1025-1349) Protein is expressed from HEK293 with His tag and Strep-II tag at the C-terminus.It contains Gln1025-Asn1349. |
Product Background |
Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. Loss of this receptor in congenital or acquired diseases results in multiple organ dysfunctions, including forebrain malformation (holoprosencephaly) and renal reabsorption defects (renal Fanconi syndrome). |
Product Category |
Recombinant Protein / Others / Other |
Human LRP2 (1025-1349) Protein (LRP-HM622) Specifications/Details
Protein |
LRP2 |
Synonyms |
LRP-2; gp330; Megalin; Glycoprotein 330 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln1025-Asn1349 |
Molecular Weight |
The protein has a predicted MW of 38.15 kDa. Due to glycosylation, the protein migrates to 45-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Strep-II |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in 10mM HEPES, 150mM NaCl, 5mM CaCl2, 0.005% Tween-20 (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Human LRP2 (1025-1349) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human LRP2 (1025-1349) is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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