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Rhesus macaque FAM171A2 Protein (FAM-RM1A2) Summary
Product Description |
Recombinant Rhesus macaque FAM171A2 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Lys30-Thr315. |
Product Background |
The FAM171A2 gene encodes a transmembrane protein, it is implicated in signaling, vesicle trafficking, and interactions with the extracellular matrix. According to the Human Protein Atlas, it is predicted to localize to the membrane, and recent data suggests interaction with DYNLL1 (Dynein Light Chain LC8-Type 1), implying a role in intracellular transport mechanisms. Emerging studies indicate that FAM171A2 may act as a neuronal receptor involved in the endocytosis of pathological α-synuclein fibrils. Overexpression of FAM171A2 promotes uptake and propagation of these fibrils, while neuronal knockdown exhibits protective effects. |
Product Category |
Recombinant Protein / Others / Other |
Rhesus macaque FAM171A2 Protein (FAM-RM1A2) Specifications/Details
Protein |
FAM171A2 |
Synonyms |
MGC34829 |
Accession |
|
Species |
Rhesus macaque |
Biotinylated |
no |
Amino Acid Range |
Lys30-Thr315 |
Molecular Weight |
The protein has a predicted MW of 32.31 kDa. Due to glycosylation, the protein migrates to 42-52 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Rhesus macaque FAM171A2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
Other Available Proteins:
Finding available proteins...
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