Seizure-Related 6 Homolog (Sez6) Proteins

Background

Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviors after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.

Synonyms

Seizure protein 6 homolog; SEZ-6; SEZ6; BSRPC; BSRP-C