We're thrilled to announce our sponsorship of PEGS EUROPE, the largest protein & antibody engineering event in Europe, taking place in Lisbon, Portugal, from November 14-16, 2023. Celebrated as "the best biologics technology meeting in Europe," this conference is a nexus for scientific exchange and inspiration.
Insightful Presentation Alert
Don't miss out on our CTO, Manhee Suh's talk, " ImmunoTherapy - Innovations in CAR Therapy" scheduled for Wednesday, November 15th at 9:45 AM. Gain insights into cutting-edge advancements directly from our leadership!
Dive into Our Research
Find our experts at booth 446! And explore our latest advances detailed in our three poster presentations:
A072: Transforming Tumor Research: Engineering MHCs as Versatile Reagents
When dealing with solid tumors lacking specific biomarkers, the effectiveness of adoptive T cell therapy using TCR-T treatments is limited. We believe that the absence of dependable, multifaceted MHC reagents has been a hindrance in the research and development of treatments for solid tumors. To address this unmet need, we have engineered MHC molecules in several formats with diverse applications and high stability. These improved, highly active MHC molecules have the potential to facilitate solid tumor research and development.
B057: GPCR VLPs & Nanodiscs for Drug Discovery
G protein-coupled receptors (GPCRs), also known as seven-transmembrane receptors, represent the most important class of drug targets. However, extraction and purification of membrane proteins like GPCRs, ion channels, and transporters are generally challenging due to low expression levels and the hydrophobic nature of transmembrane segments. To tackle this challenge, we have engineered and produced GPCRs in VLP and/or nanodisc formats, which have been successfully applied to GPCR antibody drug discovery and various in vitro assays.
B058: Tailored AAV Solutions: ELISA Kits and Customized Variant Kit Development
Adeno-associated viruses (AAVs) have been a potent tool for gene delivery. Different AAV serotypes and engineered AAV variants exhibiting a wide array of cell and tissue tropisms are employed for various therapeutic applications.
Accurate AAV capsid titer determination is vital for clinical use. Yet, isolating high-quality monoclonal antibodies (MAbs) specific to AAV serotypes is challenging due to AAV's weak immunogenicity. To overcome this, we developed an efficient mouse AAV immunization scheme, leading to strong antibody responses. Consequently, we designed top-quality AAV antibody ELISA kits. We believe our methodology can assist gene therapy companies interested in developing customized AAV ELISA kits for their AAV variations.
Event Details:
- Venue: Lisbon Congress Center, Lisbon, Portugal
- Dates: November 14 - 16, 2023
- KACTUS Booth: #446
We're looking forward to engaging with you at PEGS EUROPE 2023.
For more information, visit kactusbio.com
