Product Description |
Recombinant SARS PLpro/papain-like protease Protein is expressed from E.coli with His tag at the C-terminus.It contains Glu1541-Tyr1859. |
Product Background |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
PLpro/papain-like protease |
Synonyms |
Replicase polyprotein 1a; pp1a; nsp1; PL2-PRO; PL-PRO; Papain-like Protease; Plpro |
Accession |
|
Species |
SARS |
Biotinylated |
no |
Amino Acid Range |
Glu1541-Tyr1859 |
Molecular Weight |
The protein has a predicted MW of 36.91 kDa same as Bis-Tris PAGE result. |
Product Tag |
C-His |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in 50 mM Tris, 0.1 % Tween, 150mM NaCl (pH 9.0). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
SARS PLpro on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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