Product Description |
Recombinant APC-equivalent Human HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr305 (HLA-C 03:04), Ile21-Met119 (B2M) and GADGVGKSAL peptide. |
Product Background |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
Product Category |
Recombinant Protein |
Target |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer |
MHC Form |
Tetramer |
Allele |
HLA-C 03:04 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gly25-Thr305(HLA-C 03:04), Ile21-Met119(B2M) and GADGVGKSAL peptide |
Molecular Weight |
The protein has a predicted MW of 300.4 kDa. |
Product Tag |
C-His |
Fluorophore |
APC |
Express System |
HEK293 |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 300mM NaCl (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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