Name: APC-equivalent Human HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein (MHC-HM10CTC)
Brand: KactusBio
SKU: MHC-HM10CTC-100UG
Price: 1150.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Amino Acid Range: Gly25-Thr305(HLA-C 03:04), Ile21-Met119(B2M) and GADGVGKSAL peptide

Catalog #MHC-HM10CTC

Size

100UG

500UG

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Product Description	Recombinant APC-equivalent Human HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr305 (HLA-C 03:04), Ile21-Met119 (B2M) and GADGVGKSAL peptide.
Product Background	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Product Category	Recombinant Protein / Antibody discovery / MHC

Protein	HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer
Synonyms	MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
MHC Form	Tetramer
Allele	HLA-C 03:04
Accession	QAV56463.1(HLA-C*03:04)&P61769(B2M)&GADGVGKSAL
Species	Human
Biotinylated	no
Amino Acid Range	Gly25-Thr305(HLA-C 03:04), Ile21-Met119(B2M) and GADGVGKSAL peptide
Molecular Weight	The protein has a predicted MW of 300.4 kDa.
Product Tag	C-His
Fluorophore	APC
Expression System	HEK293
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS, 300mM NaCl (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.