Biotinylated Human TLR3 Protein (Primary Amine Labeling) (TLR-HM103B)
Catalog: TLR-HM103B
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Product Description | Recombinant Biotinylated Human TLR3 Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the C-Terminus.It contains Ser23-Glu703. |
Product Background |
TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3. |
Product Category |
Recombinant Protein |
Target |
TLR3 |
Synonyms | TLR3; CD283; IIAE2 |
Accession | |
Species |
Human |
Amino Acid Range |
Ser23-Glu703 |
Molecular Weight | The protein has a predicted MW of 78.7 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Biotinylated Human TLR3, His Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-TLR3 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22um filtered solution in PBS (pH 7.4). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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