Biotinylated Human TLR3 Protein (Primary Amine Labeling) (TLR-HM103B)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Biotinylated: yes
  • Activity: Immobilized Biotinylated Human TLR3, His Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-TLR3 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Ser23-Glu703

Catalog: TLR-HM103B

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Product Description Recombinant Biotinylated Human TLR3 Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the C-Terminus.It contains Ser23-Glu703.

Product Background

 TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.

Product Category

 Recombinant Protein

Target

 TLR3
Synonyms TLR3; CD283; IIAE2

Gene/Protein ID

 Q6PCD4

Species

 Human

Exact Sequence

 Ser23-Glu703
Molecular Weight The protein has a predicted MW of 78.7 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Biotinylated Human TLR3, His Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-TLR3 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Biotinylated Human TLR3, His Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-TLR3 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA.
The purity of Biotinylated Human TLR3 is greater than 95% as determined by SEC-HPLC.
Biotinylated Human TLR3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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