Product Description |
Recombinant Canine HE4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gly28-Phe124. |
Product Background |
The ovarian cancer biomarker HE4 is known to promote proliferation, metastasis, chemoresistance, and suppression of cytotoxic lymphocytes. HE4 has the ability to affect signaling events and gene expression in multiple cell types of the tumor microenvironment, which could contribute to angiogenesis and altered immunogenic responses in ovarian cancer. |
Product Category |
Recombinant Protein |
Target |
HE4 |
Accession |
|
Species |
Canine |
Biotinylated |
no |
Amino Acid Range |
Gly28-Phe124 |
Molecular Weight |
The protein has a predicted MW of 37.06 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Canine HE4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Canine HE4 is greater than 95% as determined by SEC-HPLC. |
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