- Express System: HEK293
- Activity: Immobilized FITC-equivalent Biotinylated Human CD20 VLP (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Ofatumumab, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test). See testing image for detail.
- Amino Acid Range: Met1-Pro297
Product Description |
Recombinant FITC-equivalent Biotinylated Human CD20 Protein-VLP is expressed from HEK293.It contains Met1-Pro297. |
Product Background |
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. |
Product Category |
Recombinant Protein |
Target |
CD20 |
Synonyms |
MS4A1; CD20; MS4A-1; B1; Bp35; CD20 receptor; CD20S7; CVID5; LEU-16; Ly-44; MS4A2; S7 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Pro297 |
Molecular Weight |
The target protein has a predicted MW of 34.3 kDa. |
Activity |
Immobilized FITC-equivalent Biotinylated Human CD20 VLP (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Ofatumumab, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test). See testing image for detail. |
Fluorophore |
FITC |
Express System |
HEK293 |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 150mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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