Name: Cynomolgus DNAM-1/CD226 Protein (DAM-CM101)
Brand: KactusBio
SKU: DAM-CM101-100UG
Price: 346.5 USD
Availability: InStock

Cynomolgus DNAM-1/CD226 Protein (DAM-CM101)

Human CD155, hFc Tag- captured on CM5 Chip via Protein A can bind Cynomolgus DNAM-1, His Tag with an affinity constant of 0.82 uM as determined in SPR assay (Biacore T200).

Immobilized Cynomolgus DNAM-1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human CD155, mFc Tag with the EC50 of 1.63ug/ml determined by ELISA (QC Test).

Cynomolgus DNAM-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Cynomolgus DNAM-1 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus DNAM-1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human CD155, mFc Tag with the EC50 of 1.63ug/ml determined by ELISA (QC Test). The affinity constant of 0.82 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Glu19-Phe252

Catalog #DAM-CM101

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus DNAM-1/CD226 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu19-Phe252.
Product Background	DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	DNAM-1/CD226
Synonyms	CD226 molecule; CD226; DNAM1; PTA1; TLiSA1
Accession	A0A2K5W1Z6-1
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Glu19-Phe252
Molecular Weight	The protein has a predicted MW of 27.7 kDa. Due to glycosylation, the protein migrates to 48-68 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus DNAM-1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human CD155, mFc Tag with the EC50 of 1.63ug/ml determined by ELISA (QC Test). The affinity constant of 0.82 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human CD155, hFc Tag- captured on CM5 Chip via Protein A can bind Cynomolgus DNAM-1, His Tag with an affinity constant of 0.82 uM as determined in SPR assay (Biacore T200).
	Immobilized Cynomolgus DNAM-1, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human CD155, mFc Tag with the EC50 of 1.63ug/ml determined by ELISA (QC Test).
	Cynomolgus DNAM-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus DNAM-1 is greater than 95% as determined by SEC-HPLC.