Name: Cynomolgus IL-23R Protein (ILR-CM123)
Brand: KactusBio
SKU: ILR-CM123-100UG
Price: 315.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Cynomolgus IL-23R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.39ug/ml determined by ELISA (QC Test). The affinity constant of 3.90 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gly24-Asp353

Catalog #ILR-CM123

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus IL-23R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly24-Asp353.
Product Background	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
Product Category	Recombinant Protein / Antibody discovery

Protein	IL-23R
Synonyms	IBD17; IL-23 R; IL-23 receptor
Accession	G7NWY5
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Gly24-Asp353
Molecular Weight	The protein has a predicted MW of 39.03 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus IL-23R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.39ug/ml determined by ELISA (QC Test). The affinity constant of 3.90 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus IL-23R, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-23 alpha&Mouse IL-12 beta, His Tag with an affinity constant of 3.90 nM as determined in SPR assay (Biacore T200).
	Immobilized Cynomolgus IL-23R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.39ug/ml determined by ELISA (QC Test).
	Cynomolgus IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus IL-23R is greater than 95% as determined by SEC-HPLC.