Cynomolgus TREM2 Protein (TRM-CM401)
Cynomolgus TREM2 Protein (TRM-CM401)
Cynomolgus TREM2 Protein (TRM-CM401)
Cynomolgus TREM2 Protein (TRM-CM401)
Cynomolgus TREM2 Protein (TRM-CM401)
Cynomolgus TREM2 Protein (TRM-CM401)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Cynomolgus TREM2, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 50.3ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: His19-Ser174
Catalog #TRM-CM401
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Product Description
 Recombinant Cynomolgus TREM2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains His19-Ser174.
Product Background
 TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2- consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.
Product Category
 Recombinant Protein
Target
 TREM2
Synonyms
 PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c
Accession
Species
 Cynomolgus
Biotinylated
 no
Amino Acid Range
 His19-Ser174
Molecular Weight
 The protein has a predicted MW of 18.5 kDa. Due to glycosylation, the protein migrates to 33-42 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Cynomolgus TREM2, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 50.3ng/ml determined by ELISA. See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus TREM2, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 50.3ng/ml determined by ELISA.
Cynomolgus TREM2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
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