FITC-Compatible Human CD19 Protein (CD1-HM119F)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Pro20-Lys291

Catalog: CD1-HM119F

$900.00
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Product Description FITC-Compatible Human CD19 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Pro20-Lys291.

Product Background

CD19 is a B-lineage-specific transmembrane glycoprotein, the expression of which is maintained on more than 95% B-cell malignancies. This strict lineage restriction makes CD19 an ideal target for immune therapies using chimeric antigen receptors (CARs). T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA approved for the treatment of relapsed or refractory large B-cell lymphoma. Despite the success and curative potential of CD19 CAR T cells, several reports describing disease relapse due to antigen loss are now emerging.

Product Category

Recombinant Protein

Target

FITC-Compatible CD19
Synonyms CD19; B4; CVID3; Leu-12; MGC12802
Accession

Species

Human

Amino Acid Range

Pro20-Lys291
Molecular Weight The protein has a predicted MW of 60.1 kDa. Due to glycosylation, the protein migrates to 68-72 kDa based on Tris-Bis PAGE result.

Product Tag

C-His

Fluorophore

FITC

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1 EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Use 100 ul FITC-Compatible Human CD19 (10 ug/ml) to detect the positive rate of 1×106 anti-CD19 CAR cells and FITC-labeled irrelevant protein (100 ul, 10 ug/ml) was served as a negative control.
The purity of FITC-Compatible Human CD19 is greater than 95% as determined by SEC-HPLC.
FITC-Compatible Human CD19 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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