Product Description |
Recombinant Biotinylated Human Claudin 18.2 Protein-VLP V2 is expressed from HEK293.It contains Met1-Val261. |
Product Background |
Claudin18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors. |
Product Category |
Recombinant Protein |
Target |
Claudin 18.2 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Val261 |
Molecular Weight |
The target protein has a predicted MW of 29 kDa. |
Activity |
The affinity constant of 16.38 pM as determined in SPR assay (Biacore T200). See testing image for detail. |
Express System |
HEK293 |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 150mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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FITC-equivalent Biotinylated Human Claudin 18.2 VLP captured on CM5 Chip via Steptavidin can bind Anti-Claudin18.2 Antibody with an affinity constant of 16.38 pM as determined in SPR assay (Biacore T200) (QC Test). |
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Loaded FITC-equivalent Biotinylated Human Claudin 18.2 VLP on SA-Biosensor, can bind Anti-Claudin18.2 Antibody with an affinity constant of 0.15 nM as determined in BLI assay (Gator Prime). |
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