Product Description |
Recombinant Cynomolgus GPRC5D Protein-VLP is expressed from HEK293.; It contains Met1-Cys300. |
Product Background |
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer. The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. |
Product Category |
Recombinant Protein |
Target |
GPRC5D VLP |
Synonyms |
GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Met1-Cys300 |
Molecular Weight |
The target protein has a predicted MW of 35.10 kDa. |
Activity |
Immobilized Cynomolgus GPRC5D VLP (100 ul/well) at 5 ug/ml (100 ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 6.91 ug/ml determined by ELISA. See testing image for detail. |
Express System |
HEK293 |
Purity |
>95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 300 mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Immobilized Cynomolgus GPRC5D VLP (100 ul/well) at 5 ug/ml (100 ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 6.91 ug/ml determined by ELISA. |
|
|
The purity of Cynomolgus GPRC5D VLP is greater than 95% as determined by SEC-HPLC. |
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