Human ACVR1B/ALK-4 Protein (ALK-HM104)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Ser24-Glu126

Catalog: ALK-HM104

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Product Description Recombinant Human ACVR1B/ALK-4 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser24-Glu126.

Product Background

Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system.

Product Category

Recombinant Protein

Target

ACVR1B/ALK-4
Accession

Species

Human

Amino Acid Range

Ser24-Glu126
Molecular Weight The protein has a predicted MW of 12.51 kDa. Due to glycosylation, the protein migrates to 15-25 kDa based on Tris-Bis PAGE result.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human ACVR1B is greater than 95% as determined by SEC-HPLC.
Human ACVR1B on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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