Human ACVR1B/Activin RIB Protein (ALK-HM104)
Human ACVR1B/Activin RIB Protein (ALK-HM104)
Human ACVR1B/Activin RIB Protein (ALK-HM104)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Ser24-Glu126
Catalog #ALK-HM104
Regular price $270.00
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Product Description
Recombinant Human ACVR1B/Activin RIB Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser24-Glu126.
Product Background
Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system.
Product Category
Recombinant Protein
Target
ACVR1B/Activin RIB
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Ser24-Glu126
Molecular Weight
The protein has a predicted MW of 12.51 kDa. Due to glycosylation, the protein migrates to 15-25 kDa based on Bis-Tris PAGE result.
Activity
The affinity constant of 0.16 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human ACVR1B, His Tag-Tag immobilized on CM5 Chip can bind Human TDGF1, His Tag-with an affinity constant of 0.16 uM as determined in SPR assay (Biacore T200).
Human ACVR1B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human ACVR1B is greater than 95% as determined by SEC-HPLC.

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