Product Description |
Recombinant Human CD42b/GP1BA Protein is expressed from HEK293 with His tag at the C-Terminus.It contains His17-Leu531. |
Product Background |
Absence of the CD42 complex leads to the Bernard-Soulier syndrome (BSS), which is a bleeding disorder characterized by thrombocytopenia and giant platelets. So far, mutations have been found in the genes encoding CD42a, CD42b and CD42c in patients with BSS**. |
Product Category |
Recombinant Protein |
Target |
CD42b/GP1BA |
Synonyms |
GP-Ib alpha; GPIb-alpha; GPIbA; GP1BA; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; VWDP; BP1BA; MGC34595 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
His17-Leu531 |
Molecular Weight |
The protein has a predicted MW of 57.6 kDa. Due to glycosylation, the protein migrates to 110-115 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CD42b, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD42b Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human CD42b, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD42b Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA (QC Test). |
|
|
Human CD42b on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human CD42b is greater than 95% as determined by SEC-HPLC. |
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