Human GCGR/Glucagon receptor Protein (GCR-HM20R)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Ala26-Lys136

Catalog: GCR-HM20R

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Product Description Recombinant Human GCGR/Glucagon receptor Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ala26-Lys136.

Product Background

The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.

Product Category

Recombinant Protein

Target

GCGR/Glucagon receptor
Accession

Species

Human

Amino Acid Range

Ala26-Lys136
Molecular Weight The protein has a predicted MW of 39.00 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.

Product Tag

C-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human GCGR is greater than 95% as determined by SEC-HPLC.
Human GCGR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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