Human GCGR/Glucagon receptor Protein (GCR-HM40R)
Catalog: GCR-HM40R
Order now get it on
| Product Description | Recombinant Human GCGR/Glucagon receptor Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Ala26-Lys136. |
Product Background |
The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles. |
Product Category |
Recombinant Protein |
Target |
GCGR/Glucagon receptor |
Gene/Protein ID |
P47871 |
Species |
Human |
Exact Sequence |
Ala26-Lys136 |
| Molecular Weight | The protein has a predicted MW of 15.96 kDa. Due to glycosylation, the protein migrates to 30-50 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Liquid |
| Shipping | Shipped with dry ice. |
| Formulation | Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
| Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
The purity of Human GCGR is greater than 95% as determined by SEC-HPLC. |
|
|
Human GCGR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
You may also be interested in
View more associated products